Polynucleotides like Plenhyage, Plinest & Nucleofill
16/05/23
What are Polynucleotides (PNs)?
These are natural DNA molecules extracted from salmon or trout sperm that are so purified that the DNA fragments are the same as human DNA. This product is injected into the skin and has been used since the 1950s for burn and wound healing. These are also known as PDRN although they are slightly different sized molecules.
How do they work?
They create a surge of fibroblast numbers and activity. These cells create collagen and elastin that are the building blocks of plump and resilient skin. They also produce lots of hydration (hyaluronic acid) in the skin. This is why it is known as a biostimulant.
What areas can be treated?
PNs are particularly great around the eyes and mouth, as these areas are prone to lost elasticity as you age. Aged, scarred and stretch-marked skin responds really well to the tightening and moisturising effects of PNs. There is also good results from Plinest Hair to improve hair loss.
This lady had 2 treatments around her eyes, however better results are seen if 3-4 treatments are given.
Is it painful to have this treatment?
As really fine needles or cannulas are used there is minimal discomfort. However topical numbing cream is always administered prior to injection. There is also the option to have a vibrating device that has been shown to help with the discomfort of needles piercing the skin.
How long do the results last?
Results last around 6 months but this will depend on your lifestyle and rate of aging.
What is the aftercare?
Strict application of SPF for 2-3 weeks. No makeup is advised for 12 hours. No lasers or excess heat for 3 weeks.
How much does it cost?
This depends on the advice given at your consultation. Procedural costs are from £350 upwards. There are multisyringe discounts if administered at the same sitting.
What can go wrong?
Thankfully, in the right hands, complications and adverse reactions are rare. However, like all injectables, there are theoretical risks of a vascular occlusion that could lead to a medical emergency, such as skin necrosis (skin death) or worse. Your injector should tell you about the possible complications. If they say there is no chance of complications, leave the clinic. The injector is either untrustworthy or has poor medical knowledge.
In the UK, counterfeit products can be very easily bought online at a fraction of the cost of the real product. Untested product can at best be ineffective (and a waste of money) or at worst cause a serious and unsightly reaction in the skin.
My advice would be, wherever you are in the country choose an aesthetic doctor who is experienced and capable of diagnosis and management of medical complications. Please make your choice of aesthetic provider based on their medical experience and qualifications and not on who can provide the cheapest treatment. A cheap deal is no comfort when a preventable complication has occurred. Wherever you are in the UK, choose your injector wisely.
More scientific details and comparisons with other injectable treatments can be found by clicking HERE
How do I book in?
If you are a new patient please book for a consultation for a detailed assessment and treatment plan.
My private clinic is 1/2 way between Chester and Wrexham in a countryside setting. I have 25 years of experience as a medical doctor including GP, aesthetics and dermatology. I give honest trustworthy advice on what will deliver results. Click on booking link or call on 07711190079
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